Dr. Chitnis is Director of the Comprehensive Longitudinal Investigation in MS at Brigham and Women’s Hospital or, the CLIMB study. CLIMB is an observational cohort, a unique study following over 2000 MS patients with annual MRI, clinical evaluations and blood studies, which has yielded over 100 publications. This observational study has served as a model for bench-bedside translational investigation of MS and the establishment of a comprehensive MS Center has been replicated throughout the United States and overseas based on the model we established at the Brigham and Women’s Hospital. Dr. Chitnis has made seminal observations on the course of MS and correlation with biomarkers funded through research grants from the National MS Society (NMSS) and the Department of Defense (DOD), including the study of neurofilament light chain as a disease activity biomarker in MS. She has directed the development of novel statistical methods including machine-learning techniques with the overall goal of developing predictive models for MS disease course and response to treatment.